421 - FRADET.qxd
نویسندگان
چکیده
Superficial transitional cell carcinomas (TCC) account for about 70% of all bladder cancers in North America and Europe [1]. Following surgery, these tumours recur in more than 60% of cases and up to 25% of recurrences become invasive. For more than 20 years, intravesical bacillus Calmette-Guérin (BCG) instillation has been used successfully to prevent recurrence and progression of superficial TCC after surgery, or for the treatment of carcinoma in situ. Nearly 50% of patients at high risk of recurrence remain free of disease after receiving BCG immunotherapy following surgery. This suggests that immunotherapeutic treatments targeting specific tumour-associated antigens might be more effective and associated with less morbidity than BCG. Bladder cancer thus offers a unique opportunity to develop cancer vaccines in an ideal setting of minimal tumour burden. However, the development of specific immunotherapy depends on the identification of relevant target antigens.
منابع مشابه
MiR-421 regulates apoptosis of BGC-823 gastric cancer cells by targeting caspase-3.
MicroRNAs might act as oncogenes or tumor suppressors in cancer. Recent studies have shown that miR-421 is up-regulated in human gastric cancer. Here, we found that miR-421 was over-expressed in gastric cancer tissues and cell lines. Bioinformatics analysis predicted that the caspase-3 gene was a target of miR-421. Caspase-3 was negatively regulated by miR-421 at the post-transcriptional level....
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We report results from our monitoring of the BL Lac object Mrk 421 in the near-IR J band. The observations, aimed at studying the intraday variability (IDV) of the object, were carried out systematically over an extended (and near-continuous) period of eight nights from the 1.2m Mount Abu Infrared Telescope, India. There are limited studies for Mrk 421 in the J band for such an extended period....
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Hypoxia and dysregulation of microRNAs (miRNAs) have been identified as crucial factors in carcinogenesis. However, the potential mechanisms of HIF-1α and miR-421 in gastric cancer have not been well elucidated. In this study, we found that miR-421 was up-regulated by HIF-1α. Overexpression of miR-421 promoted metastasis, inhibited apoptosis, and induced cisplatin resistance in gastric cancer i...
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